Rounding up the usual suspects: confirmation bias in epidemiological research

Rounding up the usual suspects in O2 sensing: CO, NO, and H2S!

Oxygen sensing by the carotid body is essential in vertebrates to adapt to reduced arterial oxygen tension. In this issue of Science Signaling, Yuan et al. report an intricate signaling system to transduce a physical parameter--oxygen tension--into a biological cellular signal (neural discharge) through changes in the production of carbon monoxide (CO), the second messenger cyclic guanosine mon...

Epigenetic Codes for Heterochromatin Formation and Silencing Rounding up the Usual Suspects

Recent results from diverse organisms point to a self-reinforcing network of interactions among the three best-characterized covalent modifications that mark heterochromatin: histone hypoacetylation, histone H3-Lys9 methylation, and cytosine methylation. These modification systems suggest a mechanistic basis for spreading of heterochromatin over large domains and for stable epigenetic inheritan...

tHe USual Suspects

A 72-year-old man presented with a short history of headaches with reduced visual acuity in his right eye. His general practitioner then referred him to the ophthalmologist who found Grade IV hypertensive retinopathy with bilateral papilloedema on fundoscopy. He was referred to a medical team for further assessment. Eleven months prior to this current presentation, the patient developed painles...

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

et al., 1994; Müller et al., 1995), chapsyn-110/PSD-93 Electrical signaling in the nervous system is depen(Brenman et al., 1996; Kim et al., 1996), and SAP102 dent on the function of a wide variety of ion channels (Müller et al., 1996). In their N-terminal half, this family in the surface membrane of neurons. These neuronal of proteins is characterized by the presence of three ion channels do n...

Identifying the “Usual Suspects”